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All submissions will be checked by i Thenticate before being sent to reviewers.---------------------------------------------------------------------Journal of Biomedical Engineering and Informatics. If you have any suitable manuscripts, please submit them to [email protected] online: Submissions Journal of Biomedical Engineering and Informatics ISSN 2377-9381(Print) ISSN 2377-939X(Online)Copyright © Sciedu Press To make sure that you can receive messages from us, please add the 'sciedu.ca' and ‘sciedupress.com’ domains to your e-mail 'safe list'.If you do not receive e-mail in your 'inbox', please check your 'spam' or 'junk' folder.Please contact the Editor in time for that.b) Peer review.
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Multi-level customized autogenous bones (MLC-Auto-Bones) are finally obtained by combining autogenous bone marrow-derived mesenchymal stem cells (Auto-BMSCs).
With autogenous materials and cells, MLC-Auto-Bones are inherently biocompatible and biosafe, providing good bioactivity for osteogenesis.
However, the limited source, biocompatibility, and biosafety of decellularized ECM are deficiencies in its large clinical use.
Autogenous ECM is biocompatible, bioactive, and biosafe, making it an optimal choice for future clinical applications of 3D printing.Here, we developed a multi-level customized 3D printing (MLC-3DP) strategy applying autogenous bone matrix (Auto-BM).This MLC-3DP includes shape specificity (shape), material specificity (Auto-BM), and cell specificity (autogenous cells) for true patient-specific repairs.In this implant, Auto-BMSCs can spontaneously differentiate into osteoblasts in vitro without additional osteogenic factors.In critical-sized skull defect models in vivo (3 months), implants integrate tightly to the defects' margin, facilitate mineralization, and generate vascularized mature bone.Contact us if you experience any difficulty logging in.is an interdisciplinary, international journal which presents original and review articles in the major fields of bioengineering and biomedical engineering.The paper will be peer-reviewed by three experts; two reviewers from outside and one editor from the journal typically involve in reviewing a submission.The review process may take 2-4 weeks.c) Notification of the result of review by E-mail.d) The authors revise paper and pay publication fee (200.00 USD).e) After publication, the corresponding author will receive the copy of printed journal, free of charge.f) E-journal in PDF is available on the journal’s webpage, free of charge for download.Auto-BM (skull flaps) is readily accessible for specific patients after craniectomy, providing sufficient autogenous materials for MLC-3DP.Under mild conditions of this strategy, human-scale 3D printed samples can be fabricated using bioactive micron-sized Auto-BM particles.