Telomerase Research Paper

Telomerase Research Paper-57
Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging.Furthermore, differences in age-related telomere attrition [...] Read more.Authors may use MDPI's English editing service prior to publication or during author revisions.

Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging.Furthermore, differences in age-related telomere attrition [...] Read more.Authors may use MDPI's English editing service prior to publication or during author revisions.

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These findings in the NMR, suggest an age buffering mechanism, while in Spalax tissues the shortening of the telomeres are in spite of its extreme longevity traits.

Therefore, using long-lived species as models for understanding the role of telomeres in longevity is of great importance since they may encompass mechanisms that postpone aging.

It also extends the function of telomerase in its non-canonical role to cell types such as neurons, and organs such as brain.

The aim of this Special Issue is to demonstrate and share new results and the growing knowledge about the roles of telomeres and telomerase during processes such as aging and cancer development. Gabriele Saretzki Manuscript Submission Information Manuscripts should be submitted online at com by registering and logging in to this website. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website.

We cross-sectionally tested telomere length in different tissues of two long-lived (naked mole-rat and Spalax) and two short-lived (rat and mice) species to tease out this enigma.

While blood telomere length of the naked mole-rat (NMR) did not shorten with age but rather showed a mild elongation, telomere length in three tissues tested in the Spalax declined with age, just like in short-lived rodents.

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